Bayern Munich looked to have guaranteed themselves a place in the Champions League quarter-finals after they romped to a second 5-1 thrashing in successive seasons over the Gunners at Allianz Arena on Wednesday, February 15.
Carlo Ancelotti's side led through Arjen Robben's early goal, before Alexis Sanchez levelled for Arsenal after his initial penalty attempt was saved by Manuel Neuer.
It was a different sorry story for the visitors after the break.
Robert Lewandowski rose high over Mustafi to put Bayern in the lead. The Pole turned provider when his backheel from a Xabi Alonso pass freed Thiago Alcantara brace to score from a one-on-one position.
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Alcantara added the fourth when his shot following a scramble in the box from a corner kick was deflected off Granit Xhaka and into the net.
The fifth came from substitute Thomas Muller who capitalized on Arsenal's sloppy passing at the back to score a left footed shot.
In the other game played on the night, Real Madrid came from behind to secure a victory in their Champions League last-16 tie with Napoli with a 3-1 victory at the Santiago Bernabeu.
Just eight minutes in, Insigne embarrassed goalkeeper Keylor Navas with a stunning first-time effort from distance after he spotted the goalie off his line.
Benzema had missed a clear chance inside the first minute but he made amends by leveling the scores with his 51st goal in the competition - one more than the previous best tally for a French player, set by Thierry Henry.
But Kroos' clever finish from a Cristiano Ronaldo cross and a thunderbolt from Casemiro effectively killed off the game in the second half.